产品特性
| Product type: |
Primary antibody |
| Antigen: |
p75 NGF Receptor |
| Immunogen: |
recombinant protein |
| Species immunized: |
Rabbit |
| Isotype: |
IgG |
| Applications: |
Western Blot (1:1200-1:5500);Immunocytochemistry (1:100-1:250);Immunoprecipitation;Immunohistochemistry (1:100-1:250);Immunofluorescence |
| Reactivity: |
Human, Mouse, Rat |
| Clonality (clone number): |
Monoclonal |
| Form: |
Liquid |
| Buffer: |
1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Concentration: |
1mg/ml |
| Purity: |
Protein A affinity purified |
| Storage: |
Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: |
|
CD271 antibody
|CD271 antigen antibody
|Gp80 LNGFR antibody
|Gp80-LNGFR antibody
|Low affinity nerve growth factor receptor antibody
|Low affinity neurotrophin receptor p75NTR antibody
|Low-affinity nerve growth factor receptor antibody
|Nerve growth factor receptor antibody
|Nerve growth factor receptor TNFR superfamily member 16 antibody
|NGF receptor antibody
|Ngfr antibody
|p75 ICD antibody
|p75 Neurotrophin receptor antibody
|p75 NTR antibody
|p75(NTR) antibody
|p75NTR antibody
|TNFR Superfamily Member 16 antibody
|TNFRSF16 antibody
|TNR16_HUMAN antibody
|Tumor necrosis factor receptor superfamily member 16 antibody
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靶标信息
Low affinity neurotrophin receptor which can bind to mature NGF, BDNF, NTF3, and NTF4 (PubMed:11559852, PubMed:1317267). Forms a heterodimeric receptor with SORCS2 that binds the precursor forms of NGF (proNGF), BDNF (proBDNF) and NTF3 (proNT3) with high affinity, and has much lower affinity for mature NGF and BDNF (PubMed:22155786, PubMed:24908487, PubMed:27457814). Plays an important role in differentiation and survival of specific neuronal populations during development (PubMed:1317267, PubMed:11559852). Can mediate cell survival as well as cell death of neural cells (PubMed:1317267, PubMed:11559852, PubMed:24908487). The heterodimeric receptor formed with SORCS2 plays a role in proBDNF-dependent synaptic plasticity, in hippocampal long term depression (LTD) and long term potentiation (LTP) (PubMed:27457814). Plays a role in the inactivation of RHOA (By similarity). Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (PubMed:22460790). Necessary for the circadian oscillation of the clock genes ARNTL/BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver (PubMed:23785138).
