Anti-IL-18 Recombinant Rabbit Monoclonal antibody
Specifications
| Product Cat#: | AB-06-5085 |
| Product type: | Primary antibody |
| Antigen: | IL-18 |
| Immunogen: | Recombinant protein within Human IL-18 aa 37-193. |
| Molecular weight: | Predicted band size: 22 kDa, Observed band size: 20 kDa |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:500-1:2000), Immunohistochemistry-Paraffin (1:2500-5000) |
| Reactivity: | Human |
| Clonality (clone number): | Monoclonal |
| Form: | Liquid |
| Buffer: | 1*TBS buffer (pH 7.4), 0.1% BSA, 40% Glycerol, 0.05% NaN3. |
| Concentration: | 1 mg/mL |
| Purity: | Protein A affinity purified. |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | Iboctadekin antibody |
| IFN gamma inducing factor antibody | |
| IFN-gamma-inducing factor antibody | |
| IGIF antibody | |
| IL 1 gamma antibody | |
| IL 18 antibody | |
| IL 1g antibody | |
| IL-1 gamma antibody | |
| IL-18 antibody | |
| IL1 gamma antibody | |
| IL18 antibody | |
| IL18 protein antibody | |
| IL18_HUMAN antibody | |
| IL1F4 antibody | |
| IL1g antibody | |
| IL1gamma antibody | |
| ILIF4 antibody | |
| Interferon gamma inducing factor antibody | |
| Interferon gamma-inducing factor antibody | |
| Interleukin 1 gamma antibody | |
| Interleukin 18 (interferon-gamma-inducing factor) antibody | |
| Interleukin 18 antibody | |
| Interleukin-1 gamma antibody | |
| Interleukin-18 antibody | |
| Interleukin18 antibody | |
| MGC12320 antibody | |
| HumanIL18 |
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Target information
Pro-inflammatory cytokine primarily involved in epithelial barrier repair, polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses (PubMed:10653850).
Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators (PubMed:14528293, PubMed:25500532).
Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells (PubMed:10653850).
Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore (PubMed:33883744).
Provider
Erpantech Laboratory