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Anti-IL-18 Rabbit Polyclonal antibody

SKU Product Brand Unit Availability Price Quantity  
AB-08-0136
Anti-IL-18 Rabbit Polyclonal antibody
Erpan Tech In stock

Specifications        

Product Cat#: AB-08-0136
Product type: Primary antibody
Antigen: IL-18
Immunogen: Synthetic peptide within mouse IL-18 aa 36-192.
Predicted molecular weight: 22 kDa
Observed molecular weight: 22/18 kDa
Species immunized: Rabbit
Isotype: IgG
Applications: Western Blot (1:400-1:2000); Immunohistochemistry-Paraffin (1:60-1:200)
Reactivity: Human, Mouse, Rat
Clonality (clone number): Polyclonal
Form: Liquid
Buffer: 1*PBS buffer (pH 7.4), 50% Glycerol, 0.05% NaN3.
Concentration: -
Purity: Immunogen affinity purified.
Storage: Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles.
Alternative names: IGIF; IL-18; IL-1g; IL1F4
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Target information

Pro-inflammatory cytokine primarily involved in epithelial barrier repair, polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses (PubMed:10653850).
Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators (PubMed:14528293, PubMed:25500532).
Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells (PubMed:10653850).
Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore (PubMed:33883744).

Provider

Erpantech Laboratory