Purified Rat Anti-Mouse Integrin αIIb (GPIIb, CD41) Monoclonal Antibody
Specifications
| Product Cat#: | M024-0 |
| Product type: | Primary antibody |
| Antigen: | Integrin αIIb (GPIIb, CD41) |
| Immunogen: | Recombinant protein |
| Species immunized: | Rat |
| Isotype: | IgG1 |
| Applications: | Immunohistochemistry; Immunoprecipitation; Generation of Fab fragments |
| Reactivity: | Mouse |
| Clonality (clone number): | Monoclonal, MwReg30 |
| Form: | Liquid |
| Buffer: | 6 mg purified immunoglobulin in PBS and 0.09% (w/v) sodium azide |
| Concentration: | 6 mg/mL |
| Purity: | Protein G affinity purified. |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | Integrin alpha-IIb; GPalpha IIb (GPIIb); Platelet membrane glycoprotein IIb |
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Target information
The MwReg30 antibody binds to murine integrin alphaIIb chain, that non-covalently associates with the beta3 chain to form the integrin alphaIIb beta3 (GPIIbIIIa), a platelet receptor for a number of ligands, including fibrinogen, von Willebrand factor, fibronectin, and vitronectin. Fab fragments of MwReg30 have been reported to specifically label platelets in experimental settings during intravital microscopy. This highly concentrated antibody preparation is optimized for digest of immunoglobulins used for in vivo platelet labeling. Use of intact IgG results in thrombocytopenia and acute systemic reactions!
Provider
Erpantech Laboratory