Purified Rat Anti-Mouse GPVI Monoclonal Antibody
Specifications
| Product Cat#: | M011-0 |
| Product type: | Primary antibody |
| Antigen: | GPVI |
| Immunogen: | Recombinant protein |
| Species immunized: | Rat |
| Isotype: | IgG2a |
| Applications: | This preparation can be used for immunoprecipitation, immunohistochemical analysis of acetone-fixed frozen sections, and immunofluorescent staining (1-3 µg/106 platelets or cells). JAQ1 recognizes mouse GPVI in a Western blot analysis under non-reducing condtions. |
| Reactivity: | Mouse |
| Clonality (clone number): | Monoclonal, JAQ1 |
| Form: | Liquid |
| Buffer: | 0.1 mg purified immunoglobulin in 20 mM Tris buffered saline containing 0.25% BSA and 0.09% (w/v) sodium azide. |
| Concentration: | 0.5 mg/mL |
| Purity: | Protein G affinity purified. |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | - |
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Target information
The JAQ1 antibody reacts with mouse GPVI, a platelet/megakaryocyte-specific 60 to 65 kDa type I transmembrane glycoprotein belonging to the immunoglobulin superfamily1. GPVI noncovalently associates with the signal-transducing FcR-chain in the platelet membrane and serves as an activating collagen receptor2. JAQ1 inhibits collagen-induced aggregation of mouse platelets. JAQ1 alone does not activate platelets. Cross-linking of JAQ1 by a secondary antibody, however, induces activation and aggregation of mouse platelets
Provider
Erpantech Laboratory