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Anti-TROP2 Chimeric antibody

SKU Product Brand Unit Availability Price Quantity  
AB-06-4796
Anti-TROP2 Chimeric antibody
Erpan Tech In stock

Specifications        

Product Cat#: AB-06-4796
Product type: Primary antibody
Antigen: TROP2
Immunogen: Recombinant protein within Human TROP2 aa27-274 (Extracellular) in HEK293 cell.
Species immunized: Mouse
Isotype: IgG1
Applications: Flow Cytometry (1:100-1:200); ELISA (1:5000-1:20000)
Reactivity: Human
Clonality (clone number): Monoclonal (A5C6)
Form: Liquid
Buffer: 1*PBS (pH7.4)
Concentration: 1 mg/ml
Purity: Protein G affinity purified.
Storage: Aliquot and freeze at -20°C. Avoid multiple freeze/thaw cycles.
Conjugate: Non-conjugated
Alternative names: Cell surface glycoprotein Trop 2 antibody
Cell surface glycoprotein Trop-2 antibody
Cell surface glycoprotein Trop2 antibody
Epithelial glycoprotein 1 antibody
GA733 1 antibody
GA7331 antibody
M1S 1 antibody
M1S1 antibody
Membrane component chromosome 1 surface marker 1 antibody
Pancreatic carcinoma marker protein GA733 1 antibody
Pancreatic carcinoma marker protein GA733-1 antibody
Pancreatic carcinoma marker protein GA7331 antibody
TACD 2 antibody
TACD2_HUMAN antibody
TACSTD 2 antibody
Tacstd2 antibody
Trop 2 antibody
Trop2 antibody
Tumor associated calcium signal transducer 2 precursor antibody
Tumor-associated calcium signal transducer 2 antibody
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Target information

Tumor-associated calcium signal transducer 2, also known as Trop-2 and as epithelial glycoprotein-1 antigen (EGP-1), is a protein that in humans is encoded by the TACSTD2 gene. This intronless gene encodes a carcinoma-associated antigen defined by the monoclonal antibody GA733. This antigen is a member of a family including at least two type I membrane proteins. It transduces an intracellular calcium signal and acts as a cell surface receptor. Mutations of this gene result in gelatinous drop-like corneal dystrophy, an autosomal recessive disorder characterized by severe corneal amyloidosis leading to blindness. This antigen is the target of sacituzumab govitecan, an antibody-drug conjugate. TROP-2 is related to epithelial cell adhesion molecule (EpCAM), also called TROP-1, gp40, and KSA. Trop-1 and Trop-2 are homologous to serum IGF-II-binding proteins and appear as signal transducers. Thus, they likely represent novel cell-surface receptors and may play a role in regulating the growth of carcinoma cells. This human monoclonal chimeric antibody has been engineered from the mouse monoclonal parent antibody. By necessity, some mouse sequence is retained as part of the variable domain. When multiplexing with other mouse-derived antibodies, using cross absorbed Fc-reactive secondary antibodies are recommended.

Provider

Erpantech Laboratory