Anti-SRSF2 Rabbit Polyclonal antibody
Specifications
| Product Cat#: | AB-08-0155 |
| Product type: | Primary antibody |
| Antigen: | SRSF2 |
| Immunogen: | Synthetic peptide corresponding to a sequence within amino acids 1-100 of human SRSF2. |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:500-1:2000); Immunohistochemistry-Paraffin (1:50-200) |
| Reactivity: | Human, Mouse, Rat |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | 1*PBS buffer (pH 7.4), 50% Glycerol, 0.01% thiomersal. |
| Concentration: | - |
| Purity: | Immunogen affinity purified. |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | SRSF2; PR264; SC-35; SC35; SFRS2; SFRS2A; SRp30b |
Target information
Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5′- and 3′-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre-mRNA. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5′- and 3′-splice site binding components, U1 snRNP and U2AF. Binds to purine-rich RNA sequences, either 5′-AGSAGAGTA-3′ (S=C or G) or 5′-GTTCGAGTA-3′. Can bind to beta-globin mRNA and commit it to the splicing pathway. The phosphorylated form (by SRPK2) is required for cellular apoptosis in response to cisplatin treatment.
Provider
Erpantech Laboratory