Anti-P4HB Recombinant Rabbit Monoclonal antibody
Specifications
| Product Cat#: | AB-06-5084 |
| Product type: | Primary antibody |
| Antigen: | P4HB |
| Immunogen: | Recombinant protein within Human P4HB aa 360-508/508. |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:1000-1:10000), Immunohistochemistry-Paraffin (1:50-200), Immunofluorescence-Cell (1:50-1:100), Flow Cytometry (1:50-1:100) |
| Reactivity: | Human, Mouse, Rat |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | 1*TBS buffer (pH 7.4), 0.05% BSA, 40% Glycerol, 0.05% NaN3. |
| Concentration: | 1 mg/mL |
| Purity: | Protein A affinity purified. |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | Cellular thyroid hormone binding protein antibody |
| Cellular thyroid hormone-binding protein antibody | |
| Collagen prolyl 4 hydroxylase beta antibody | |
| Disulphide Isomerase antibody | |
| DSI antibody | |
| EC 5.3.4.1 antibody | |
| Endoplasmic reticulum resident protein 59 antibody | |
| ER protein 59 antibody | |
| ERBA2L antibody | |
| ERp59 antibody | |
| GIT antibody | |
| Gltathione insulin transhydrogenase antibody | |
| Glutathione insulin transhydrogenase antibody | |
| P4HB antibody | |
| P4Hbeta antibody | |
| p55 antibody | |
| PDI antibody | |
| PDIA1 antibody | |
| PDIA1_HUMAN antibody | |
| PDIR antibody | |
| PHDB antibody | |
| PO4DB antibody | |
| PO4HB antibody | |
| Procollagen proline 2 oxoglutarate 4 dioxygenase (proline 4 hydroxylase) beta polypeptide (protein disulfide isomerase associated 1) antibody | |
| Procollagen proline 2 oxoglutarate 4 dioxygenase beta subunit antibody | |
| PROHB antibody | |
| Prolyl 4 hydroxylase beta polypeptide antibody | |
| Prolyl 4 hydroxylase beta subunit antibody | |
| Prolyl 4 hydroxylase subunit beta antibody | |
| Prolyl 4-hydroxylase subunit beta antibody | |
| Protein disulfide isomerase associated 1 antibody | |
| Protein disulfide isomerase, family A, member 1 antibody | |
| Protein disulfide isomerase/oxidoreductase antibody | |
| Protein disulfide-isomerase antibody | |
| Protocollagen hydroxylase antibody | |
| Thbp antibody | |
| Thyroid hormone binding protein p55 antibody | |
| Thyroid hormone binding protein p55 cellular antibody | |
| V erb a avian erythroblastic leukemia viral oncogene homolog 2 like antibody |
Target information
This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations and following phosphorylation by FAM20C, functions as a chaperone that inhibits aggregation of misfolded proteins (PubMed:32149426).
At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts as a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP. Receptor for LGALS9; the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration (PubMed:21670307).
Provider
Erpantech Laboratory