Anti-IDO antibody
Specifications
| Product Cat#: | AB-06-2339 |
| Product type: | Primary antibody |
| Antigen: | IDO |
| Immunogen: | Recombinant full length IDO of mouse origin. |
| Species immunized: | Rat |
| Isotype: | IgG |
| Applications: | Western Blot (1:500-1:2000); Immunoprecipitation: 1-2 μg per 100-500 μg of total protein (1 ml of cell lysate); Immunofluorescence (1:100-500); Immunohistochemistry (Paraffin) (1:80-1:200) |
| Reactivity: | Mouse and Human |
| Clonality (clone number): | Monoclonal (1G1) |
| Form: | Liquid |
| Buffer: | 1*TBS (pH7.4), 1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | 3-dioxygenase antibody |
| I23O1_HUMAN antibody | |
| IDO 1 antibody | |
| IDO antibody | |
| IDO-1 antibody | |
| IDO1 antibody | |
| INDO antibody | |
| indolamine 2,3 dioxygenase antibody | |
| Indole 2 3 dioxygenase antibody | |
| indoleamine 2 3 dioxygenase 1 antibody | |
| indoleamine 2 3 dioxygenase antibody | |
| Indoleamine 2,3-dioxygenase 1 antibody | |
| Indoleamine pyrrole 2 3 dioxygenase antibody | |
| Indoleamine-pyrrole 2 antibody |
Target information
Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway (PubMed:17671174). Involved in the peripheral immune tolerance, contributing to maintain homeostasis by preventing autoimmunity or immunopathology that would result from uncontrolled and overreacting immune responses (PubMed:25691885). Tryptophan shortage inhibits T lymphocytes division and accumulation of tryptophan catabolites induces T-cell apoptosis and differentiation of regulatory T-cells (PubMed:25691885). Acts as a of anti-tumor immunity (PubMed:23103127,PubMed:25157255, PubMed:14502282, PubMed:25691885). Limits the growth of intracellular pathogens by depriving tryptophan (PubMed:25691885). Protects the fetus from maternal immune rejection (PubMed:25691885).
Provider
Erpantech Laboratory