Anti-A2M antibody
Specifications
| Product Cat#: | AB-06-0105 |
| Product type: | Primary antibody |
| Antigen: | A2M |
| Immunogen: | Recombinant protein |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:500-1:2000); Immunohistochemistry (1:100-1:200) |
| Reactivity: | Human |
| Clonality (clone number): | Monoclonal, JM81-41 |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1% BSA, 40% glycerol, 0.05% NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | A2m antibody |
| A2MG_HUMAN antibody | |
| Alpha 2 M antibody | |
| Alpha 2M antibody | |
| Alpha-2-M antibody |
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target information
Is able to inhibit all four classes of proteinases by a unique ‘trapping’ mechanism. This protein has a peptide stretch, called the ‘bait region’ which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.
Provider
Erpantech Laboratory