Anti-4E-BP1 antibody
Specifications
| Product Cat#: | AB-06-0086 |
| Product type: | Primary antibody |
| Antigen: | 4E-BP1 |
| Immunogen: | Full length 4E-BP1 of human mouse origin |
| Species immunized: | Mouse |
| Isotype: | IgG1 |
| Applications: | Western Blot (1:100-2000); Immunoprecipitation: 1-2 μg per 100-500 μg of total protein (1 ml of cell lysate); Immunofluorescence (1:100-500); Immunohistochemistry (1:100-500) |
| Reactivity: | Mouse, Rat and Human |
| Clonality (clone number): | Monoclonal, 3G1 |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1% BSA, 40% glycerol, 0.05% NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | 4E-BP1 antibody |
| 4EBP1 antibody | |
| 4EBP1_HUMAN antibody | |
| BP 1 antibody | |
| EIF4E binding protein 1 antibody | |
| EIF4E-binding protein 1 antibody | |
| Eif4ebp1 antibody | |
| Eukaryotic translation initiation factor 4E-binding protein 1 antibody | |
| PHAS-I antibody | |
| PHASI antibody | |
| Phosphorylated heat- and acid-stable protein regulated by insulin 1 antibody |
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Target information
Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways.
Provider
Erpantech Laboratory